abstract：:Low glucose stimulated phosphorylation of pregnane X receptor (PXR) at Ser350 in correlation with an increased gluconeogenesis in human hepatoma-derived HepG2 cells. Only glucose, but neither insulin nor glucagon, stimulated this phosphorylation. Here, serine/threonine kinase, vaccinia related kinase 1 (VRK1)-mediated...

journal_title：Cellular signalling

authors： Gotoh S,Miyauchi Y,Moore R,Negishi M

更新日期：2017-12-01 00:00:00

abstract：:Reelin is a secreted glycoprotein and essential for brain development and plasticity. Recent studies provide evidence that Reelin modifies platelet actin cytoskeletal dynamics. In this study we sought to dissect the contribution of Reelin in arterial thrombus formation. Here we analyzed the impact of Reelin in arteria...

journal_title：Cellular signalling

authors： Gowert NS,Krüger I,Klier M,Donner L,Kipkeew F,Gliem M,Bradshaw NJ,Lutz D,Köber S,Langer H,Jander S,Jurk K,Frotscher M,Korth C,Bock HH,Elvers M

更新日期：2017-12-01 00:00:00

abstract：:Non-alcoholic fatty liver disease is the most commonly occurring chronic liver disease, and hepatic steatosis, a condition defined as extensive lipid accumulation in hepatocytes, is associated with liver dysfunction and metabolic diseases, such as, obesity and type II diabetes. Apelin is an adipokine that acts on a G ...

journal_title：Cellular signalling

authors： Huang J,Kang S,Park SJ,Im DS

更新日期：2017-11-01 00:00:00

abstract：:Cellular signal transmission requires the dynamic formation of spatiotemporally controlled molecular interactions. At the cell surface information is received by receptor complexes and relayed through intracellular signaling platforms which organize the actions of functionally interacting signaling enzymes and substra...

journal_title：Cellular signalling

authors： Torres-Quesada O,Mayrhofer JE,Stefan E

更新日期：2017-09-01 00:00:00

abstract：:Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. ...

journal_title：Cellular signalling

authors： Wnorowski A,Such J,Paul RK,Wersto RP,Indig FE,Jozwiak K,Bernier M,Wainer IW

更新日期：2017-08-01 00:00:00

abstract：:Receptor for Activated C-Kinase 1 (RACK1) belongs to the WD40 family of proteins, known to act as scaffolding proteins in interaction networks. Accordingly, RACK1 is found to have numerous interacting partners ranging from kinases and signaling proteins to membrane bound receptors and ion channels. Interestingly, RACK...

journal_title：Cellular signalling

authors： Nielsen MH,Flygaard RK,Jenner LB

更新日期：2017-07-01 00:00:00

abstract：:Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development. In this study, we demonstrated for the first time that CMPK was overexpressed in human ovarian epithelial borderline and...

journal_title：Cellular signalling

authors： Zhou D,Zhang L,Sun W,Guan W,Lin Q,Ren W,Zhang J,Xu G

更新日期：2017-07-01 00:00:00

abstract：:About 40,000 American women die from metastatic breast cancer each year despite advancements in treatment. Approximately, 15% of breast cancers are triple-negative for estrogen receptor, progesterone receptor, and HER2. Triple-negative cancer is characterized by more aggressive, harder to treat with conventional appro...

journal_title：Cellular signalling

authors： Maiti A,Takabe K,Hait NC

更新日期：2017-04-01 00:00:00

abstract：:CK1δ and CK1ε are unique in the casein kinase 1 family and play critical roles in a number of physiological intracellular pathways. In particular, these kinases are involved in composing the mammalian circadian clock by phosphorylating core clock proteins. Considering that CK1δ/ε phosphorylate other key biological mol...

journal_title：Cellular signalling

authors： Yang Y,Xu T,Zhang Y,Qin X

更新日期：2017-02-01 00:00:00

abstract：:Understanding the underlying mechanism by which cancer cells acquire resistance to radiation and favorably selected for its clonal expansion will provide molecular insight into tumor recurrence at the treatment site. In the present study, we investigated the molecular mechanisms prompted in MCF-7 breast cancer cells i...

journal_title：Cellular signalling

authors： Yu H,Aravindan N,Xu J,Natarajan M

更新日期：2017-02-01 00:00:00

abstract：:JNK proteins are conserved stress-activated MAP kinases. In C. elegans, the JNK-homolog KGB-1 plays essential roles in protection from heavy metals and protein folding stress. However, the contributions of KGB-1 are age-dependent, providing protection in larvae, but reducing stress resistance and shortening lifespan i...

journal_title：Cellular signalling

authors： Zhang Z,Liu L,Twumasi-Boateng K,Block DH,Shapira M

更新日期：2017-01-01 00:00:00

abstract：:Recycling of the majority of agonist-internalized GPCR is dependent on a type I-PDZ "barcode" in their C-tail. The recycling of wild-type (WT) ß1-AR is also dependent on its default "type-1 PDZ barcode", but trafficking of the ß1-AR is inhibited when PKA or its substrate serine at position 312 (Ser312) are inactivated...

journal_title：Cellular signalling

authors： Nooh MM,Bahouth SW

更新日期：2017-01-01 00:00:00

abstract：:An important therapeutic method of glioblastoma, the most common primary brain tumor, is radiotherapy. However, several studies reported recently that radiation could also promote the invasion and migration of malignant tumor. Herein, we have identified that a significant increase of migration and invasiveness of huma...

journal_title：Cellular signalling

authors： Xiong Y,Ji W,Fei Y,Zhao Y,Wang L,Wang W,Han M,Tan C,Fei X,Huang Q,Liang Z

更新日期：2017-01-01 00:00:00

abstract：:Sec8 is one of the subunits of the exocyst, which is an evolutionarily conserved complex of eight proteins, comprising Sec3 (EXOC1), Sec5 (EXOC2), Sec6 (EXOC3), Sec8 (EXOC4), Sec10 (EXOC5), Sec15 (EXOC6), Exo70 (EXOC7), and Exo84 (EXOC8) subunits. Sec8 knockout mice embryos initiate gastrulation but are unable to prog...

journal_title：Cellular signalling

authors： Tanaka T,Goto K,Iino M

更新日期：2017-01-01 00:00:00

abstract：:Endothelial migration and proliferation are fundamental processes in angiogenesis and wound healing of injured or inflamed vessels. The present study aimed to investigate the regulation of the Eph/ephrin-system during endothelial proliferation and the impact of the ligand ephrin-A1 on proliferation and migration of hu...

journal_title：Cellular signalling

authors： Wiedemann E,Jellinghaus S,Ende G,Augstein A,Sczech R,Wielockx B,Weinert S,Strasser RH,Poitz DM

更新日期：2017-01-01 00:00:00

abstract：:In eukaryotes, proper loading and activation of MCM helicase at chromosomal origins plays a central role in DNA replication. Activation of MCM helicase requires its association with CDC45-GINS complex, but the mechanism of how this complex activates MCM helicase is poorly understood. Here we identified SIK1 (salt-indu...

journal_title：Cellular signalling

authors： Joshi K,Shah VJ,Maddika S

更新日期：2016-12-01 00:00:00

abstract：:Macrophages play many different roles in tissue inflammation and immunity, and the plasticity of macrophage polarization is closely associated with acute inflammatory responses. O-GlcNAcylation is an important type of post-translational modification, which subtly modulates inflammation responses. Transforming growth f...

journal_title：Cellular signalling

authors： Zhang D,Xu Z,Tao T,Liu X,Sun X,Ji Y,Han L,Qiu H,Zhu G,Shen Y,Zhu L,Shen A

更新日期：2016-11-01 00:00:00

abstract：:The mitotic inhibitor securin is degraded via the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C)-Cdc20 after anaphase onset. This triggers activation of the mitotic protease separase and thereby sister chromatid separation. However, only a proportion of securin molecules are degraded at metaphase-anapha...

journal_title：Cellular signalling

authors： Hatano Y,Naoki K,Suzuki A,Ushimaru T

更新日期：2016-10-01 00:00:00

abstract：:The CCN family is composed of six cysteine-rich, modular, and conserved proteins whose functions span a variety of tissues and include cell proliferation, adhesion, angiogenesis, and wound healing. Roles for the CCN proteins throughout the entire body including the skin, kidney, brain, blood vessels, hematopoietic com...

journal_title：Cellular signalling

authors： Piszczatowski RT,Lents NH

更新日期：2016-10-01 00:00:00

abstract：:Suppressor of Fused (SuFu) plays a conservative role in the regulation of the Gli transcription factors within the Hedgehog (Hh) signaling pathway. Despite the central importance of SuFu in the Hh pathway, little is known about its regulation. Here, we performed a GAL4-based yeast two-hybrid screen using human SuFu as...

journal_title：Cellular signalling

authors： Wang Y,Li Y,Hu G,Huang X,Rao H,Xiong X,Luo Z,Lu Q,Luo S

更新日期：2016-09-01 00:00:00

abstract：:Follistatin-like 1 (FSTL1) functions as a pivotal modulator of inflammation and is implicated in many inflammatory diseases such as rheumatoid arthritis. Here, we report that FSTL1 is strongly upregulated and secreted during osteoclast differentiation of bone marrow-derived macrophages (BMMs) and that FSTL1 positively...

journal_title：Cellular signalling

authors： Kim HJ,Kang WY,Seong SJ,Kim SY,Lim MS,Yoon YR

更新日期：2016-09-01 00:00:00

abstract：:Although increasing evidence demonstrated that deregulation of mircoRNA-503 (miRNA-503) contributes to tumorigenesis, little is known about the biological role and intrinsic regulatory mechanisms of miR-503 in prostate cancer (PCa). In present study, we found that miR-503 was significantly downregulated in advanced PC...

journal_title：Cellular signalling

authors： Jiang X,Chen Y,Du E,Yang K,Zhang Z,Qi S,Xu Y

更新日期：2016-09-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling plays a key role in regulating normal cell growth and differentiation, and mutations affecting members of this pathway contribute to cancer development and metastasis. In DNA mismatch repair (MMR)-deficient colorectal cancers that exhibit the microsatellite instability (M...

journal_title：Cellular signalling

authors： Lee J,Katzenmaier EM,Kopitz J,Gebert J

更新日期：2016-08-01 00:00:00

abstract：:Ketone bodies β-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BH...

journal_title：Cellular signalling

authors： Rojas-Morales P,Tapia E,Pedraza-Chaverri J

更新日期：2016-08-01 00:00:00

abstract：:Phosphodiesterases 4 (PDE4) act as proinflammatory enzymes via degradation of cAMP, whereas PDE4 inhibitors play an anti-inflammatory role in vitro and in vivo. In particular, apremilast has been recently approved for the treatment of psoriasis and psoriatic arthritis. However, little is known on the expression patter...

journal_title：Cellular signalling

authors： Schafer PH,Truzzi F,Parton A,Wu L,Kosek J,Zhang LH,Horan G,Saltari A,Quadri M,Lotti R,Marconi A,Pincelli C

更新日期：2016-07-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that can regulate various physiological and pathological processes. The expression of S1P has been detected in human follicular fluid. In addition, two S1P receptors, S1P1 and S1P3, are expressed at a high level in human granulosa cells. Cyclooxygenase-2 (COX-2...

journal_title：Cellular signalling

authors： Cheng JC,Chang HM,Liu PP,Leung PC

更新日期：2016-06-01 00:00:00

abstract：:By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo kinases MST1/2 together with the MOB1 scaffold protein promote the formation of active MOB1/LATS complexes which phosphorylate and thereby inhibit YAP1. However, the...

journal_title：Cellular signalling

authors： Hoa L,Kulaberoglu Y,Gundogdu R,Cook D,Mavis M,Gomez M,Gomez V,Hergovich A

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Endovascular interventions performed for atherosclerotic lesions trigger excessive vascular smooth muscle cell (SMC) proliferation leading to intimal hyperplasia. Our previous studies show that following endovascular injury, elevated TGF-β/Smad3 promotes SMC proliferation and intimal hyperplasia. Furthermore ...

journal_title：Cellular signalling

authors： DiRenzo DM,Chaudhary MA,Shi X,Franco SR,Zent J,Wang K,Guo LW,Kent KC

更新日期：2016-05-01 00:00:00

abstract：:We have previously demonstrated the existence of two phenotypically distinct cell subsets in estrogen receptor (ER)-positive breast cancer (BC) based on their differential response to a Sox2 reporter (SRR2), with reporter responsive (RR) cells being more tumorigenic and stem-like than reporter unresponsive (RU) cells....

journal_title：Cellular signalling

authors： Alqahtani H,Gopal K,Gupta N,Jung K,Alshareef A,Ye X,Wu F,Li L,Lai R

更新日期：2016-02-01 00:00:00

abstract：:We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, RagD in particular, to interfere with mTORC1 activity in amino acid sc...

journal_title：Cellular signalling

authors： Kwak SS,Kang KH,Kim S,Lee S,Lee JH,Kim JW,Byun B,Meadows GG,Joe CO

更新日期：2016-02-01 00:00:00

abstract：:CCN1/CYR61 is a matricellular protein of the CCN family, comprising six secreted proteins specifically associated with the extracellular matrix (ECM). CCN1 acts as an enhancer of the cutaneous wound healing process by preventing hypertrophic scar formation through induction of myofibroblast senescence. In liver fibros...

journal_title：Cellular signalling

authors： Borkham-Kamphorst E,Steffen BT,Van de Leur E,Haas U,Tihaa L,Friedman SL,Weiskirchen R

更新日期：2016-01-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) define a specific group of eukaryotic protein kinases which regulate a number of cellular functions by transducing extracellular signals to intracellular responses. Unlike other protein kinases, catalytic activation of MAPKs by MAPKKs depends on dual phosphorylation at two tyr...

journal_title：Cellular signalling

authors： Vázquez B,Soto T,del Dedo JE,Franco A,Vicente J,Hidalgo E,Gacto M,Cansado J,Madrid M

更新日期：2015-12-01 00:00:00

abstract：:Cardiac hypertrophy is accompanied by excessive collagen deposition in the heart. Despite painstaking research on this fatal disease, the precise role of molecular chaperones in myocardial fibrosis has not yet been elucidated. In this study, we have analyzed the mechanism by which Heat shock protein 90 (Hsp90)/Cell di...

journal_title：Cellular signalling

authors： Datta R,Bansal T,Rana S,Datta K,Chattopadhyay S,Chawla-Sarkar M,Sarkar S

更新日期：2015-12-01 00:00:00

abstract：:Cell cycle progression from G2 phase into mitosis is regulated by a complex network of mechanisms, all of which finally control the timing of Cyclin B/CDK1 activation. PLK1 regulates a network of events that contribute to regulating G2/M phase progression. Here we have used a proteomics approach to identify proteins t...

journal_title：Cellular signalling

authors： Pinder A,Loo D,Harrington B,Oakes V,Hill MM,Gabrielli B

更新日期：2015-11-01 00:00:00

abstract：:Reduced connexin43 (Cx43) expression is frequently detected in different types of human cancer. Cx43 has been shown to regulate cancer cell migration in a cell-type dependent manner. In both primary and recurrent human ovarian cancer, overexpression of TGF-β ligand and its receptors have been detected. TGF-β can regul...

journal_title：Cellular signalling

authors： Qiu X,Cheng JC,Zhao J,Chang HM,Leung PC

更新日期：2015-10-01 00:00:00

abstract：:The ubiquitously expressed phosphoinositide 3-kinase (PI3K) family of lipid kinases control diverse cellular functions including cell survival, proliferation, metabolism and migration. Class I PI3Ks generate two distinct 3-phosphoinositide lipid messengers, PI(3,4,5)P3 (PIP3) and PI(3,4)P2, that recruit signaling effe...

journal_title：Cellular signalling

authors： Li H,Marshall AJ

更新日期：2015-09-01 00:00:00

abstract：:The p53 tumor suppressor protein is a transcription factor activated by phosphorylation of its N-terminus. MDM2, encoded by a p53-activated gene, acts as a negative-feedback regulator of p53 by promoting p53 degradation. Moreover, MDM2 inhibits p53 by binding to and concealing its N-terminal transcription-activating d...

journal_title：Cellular signalling

authors： Zajkowicz A,Gdowicz-Kłosok A,Krześniak M,Ścieglińska D,Rusin M

更新日期：2015-09-01 00:00:00

abstract：:Growing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of major depression and that inflammatory processes may influence the antidepressant treatment response. Depressed patients exhibit increased levels of inflammatory markers in both the periphery and brain, and h...

journal_title：Cellular signalling

authors： Daniele S,Da Pozzo E,Zappelli E,Martini C

更新日期：2015-08-01 00:00:00

abstract：:The type II epithelial-mesenchymal transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on sig...

journal_title：Cellular signalling

authors： Desai P,Yang J,Tian B,Sun H,Kalita M,Ju H,Paulucci-Holthauzen A,Zhao Y,Brasier AR,Sadygov RG

更新日期：2015-07-01 00:00:00

abstract：:Macrophages are projected as one of the key players responsible for the progression of cancer. Classically activated (M1) macrophages are pro-inflammatory and have a central role in host defense, while alternatively activated (M2) macrophages are associated with immunosuppression. Macrophages residing at the site of n...

journal_title：Cellular signalling

authors： Ghosh S,Mukherjee S,Choudhury S,Gupta P,Adhikary A,Baral R,Chattopadhyay S

更新日期：2015-07-01 00:00:00